CAS 128-09-6 N-chlorosuccinimide
N-chlorosuccinimide CAS 128-09-6 , a white powder or crystal, is mainly used in the synthesis of chlorinating agents and antibiotics.
Chinese name: N-chlorosuccinimide
Foreign name: N-Chlorosuccinimide
Nickname: N-chlorosuccinimide N-chlorosuccinimide succinyl chloride succinimide succinyl chloride imide
Chemical formula: C4H4ClNO2
Molecular weight: 133.53
Melting point: 144 ℃
Density: 1.5g/cm3
CAS: 128-09-6
EINECS: 204-878-8
Physical and chemical properties
This product is a white crystal, soluble in water and alcohols
Melting point: 144-150 ℃
Relative density: 1.5g/cm3
Purpose
1. An important chlorinating agent that can chlorinate aromatic aldehydes without affecting the aromatic ring. In the chlorination (ortho dominant) of aniline and N-alkylaniline, the chlorination of a-aminopyridine, the dehydrochlorination and degradation chlorination of a-phenylthioamide, as well as the monochlorination of cyclopentadiene, the yield is higher than using chlorine gas, tert butyl hypochlorite, chloramine T. As an oxidant, it can oxidize diols to lactones, primary (secondary) alcohols to aldehydes (ketones), and B-hydroxyketones to B-diketones. Selective cleavage of peptide bonds formed by tryptophan under acidic conditions. It can also be used for the synthesis of allylamine, B, R-unsaturated amino acids, and their derivatives.
2. Pharmaceutical intermediates. Commonly used in the synthesis of antibiotics, such as benzyl cephalosporins, can also be used to prepare rubber additives.
3. N-chlorosuccinimide (NCS) is a convenient electrophilic addition and substitution reagent commonly used for the chlorination of sulfides, sulfones, and ketones, as well as for the synthesis of N-chloroamines.
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