Propranolol hydrochloride CAS 318-98-9 is a white or milky white crystalline powder, odorless, slightly sweet and bitter in taste. Its physical properties are stable at room temperature, and its salt has a melting point of 163-164 ℃. It is easily soluble in methanol due to weight loss during drying, slightly soluble in water, glacial acetic acid, and ethanol, slightly soluble in chloroform, extremely insoluble in ethylene glycol, and almost insoluble in ether, benzene, and ethyl acetate; In dilute acid, the side chain undergoes oxidation and decomposition, and under alkaline conditions, more stable left-handed bodies are present than right-handed bodies, using racemates.

Chinese name: Propranolol hydrochloride

Chinese synonym: 1-isopropylamino-3- (1-naphthyloxy) -2-propanol hydrochloride; Propranolol hydrochloride; Propranolol hydrochloride standard; Propranolol hydrochloride; Propranolol hydrochloride 25G; (±) – Propranolol hydrochloride, 99%; (±) – Propranolol hydrochloride; Propranolol chloride

English name: Propranololhydrochloride

English synonyms: (RS) -1- [(1-METHYLETHYL) AMINO] -3- (1-NAPHTHALENYLOXY) -2- PROPANOLHYDROCHLORIDE; PROPRANOLOLOLHCL; (+/-) – PROPRANOLOLYDROCHLORIDE; PROPRANOLOLOLHYDROCHLORIDE; (+/-) – PROPANOLOLHCL; PROPANOLOLHYDROCHLORIDE; DL Propranololhydrochloride, 99% 5GR; Propranolol Hydrochloride (200mg)

CAS number: 318-98-9

Molecular formula: C16H22ClNO2

Molecular weight: 295.8

EINECS number: 206-268-7

Pharmacological action

1. Propranolol is a non-selective competitive inhibitor β Adrenaline receptor blockers. Blocking the heart β one β 2 receptors, which antagonize sympathetic nerve stimulation and catecholamine effects, reduce the contractile force and velocity of the heart, slow down the conduction velocity through the conduction system, weaken the heart’s response to exercise and stimulation, reduce myocardial oxygen consumption, increase exercise tolerance, and can be used to treat angina pectoris.

2. Adrenergic stimulation that inhibits cardiac pacemaker potential is used to treat arrhythmias. This product can also be used to treat hypertension by blocking central and adrenergic neurons, inhibiting renin release, and reducing cardiac output.

3. Competitive antagonism against the effects of isoproterenol and norepinephrine, blocking β 2 receptors, reducing plasma renin activity. May cause bronchospasm. Suppress insulin secretion, increase blood sugar, mask symptoms of hypoglycemia, and delay the recovery of hypoglycemia.

4. It has a significant antiplatelet aggregation effect, which is mainly related to its membrane stabilizing effect and inhibition of platelet membrane Ca2+transport.

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