IndomethacinCAS 53-86-1 , also known as 2-methyl-1- (4-chlorobenzoyl) -5-methoxy-1H indole-3-acetic acid, belongs to BCS Class II drugs with high permeability, low solubility, poor dissolution, and low in vivo bioavailability. Indomethacin is a non steroidal anti-inflammatory drug (NSAIDs) with anti-inflammatory, antipyretic, and analgesic effects. It exerts anti-inflammatory effects by inhibiting cyclooxygenase and reducing prostaglandin synthesis, while antipyretic effects are related to inhibiting prostaglandin synthesis in the hypothalamus

Specification

Melting point: 158-162 ° C

Boiling point: 499.4 ± 45.0 ° C

Density: 1.2135

Refractive index: 1.6800

Appearance: White to off white powder

Application

Indomethacin is anti-inflammatory and has a significant antipyretic effect. It is mainly used for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, etc. that are not easily tolerated or have no significant therapeutic effects on salicylic acid drugs.

As a non hormonal anti-inflammatory and analgesic drug pathway cyclooxygenase (COX) inhibitor, selectively inhibits COX-1; Block the biosynthesis of prostate cord.

Medically, it has anti-inflammatory and antipyretic effects, and is mainly used for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, etc. that are not easily tolerated or have no significant therapeutic effects on salicylic acid drugs.

Packing

25kg/bag

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