N-acetylglucosamine (NAG) CAS 7512-17-6 is a fundamental component of many important polysaccharides in biological cells, especially in the exoskeleton of crustaceans, which have the highest content. It is an important prerequisite for the synthesis of bifidogenic factors and has many important physiological functions in organisms. For example, it can be used as a monomer of chitin by β- 1,4-glycosidic bonds are linked to form chitin. The chemical formula is C8H15NO6. It is a white powder. It has the property of being easily soluble in water. It has anti-inflammatory, anti-tumor and antioxidant effects. It is a drug for the treatment of osteoarthritis and rheumatoid arthritis clinically. It is widely used in food, medicine, cosmetics and other fields. It can be used as a food antioxidant, a food additive for infants, and a sweetener for diabetes patients. Mainly used in clinical practice to enhance the function of the human immune system, inhibit the excessive growth of cancer cells or fibroblasts, and have inhibitory and therapeutic effects on cancer and malignant tumors; It can provide effective treatment for various inflammations, as well as for osteoarthritis and joint pain.

Chinese name: N-acetylglucosamine

Foreign name: N-acetyl-D – (+) – glucosamine

Nickname: N-acetyl-D-glucosamine; 2- (acetylamino) -2-deoxy-D-glucose; N-acetylglucosamine; N-Acetyl-D-glucosamine

Chemical formula: C8H15NO6

Molecular weight: 221.21

CAS login number: 7512-17-6

EINECS login number: 231-368-2

Melting point: 215 ℃

Water solubility: easily soluble

Appearance: White powder

Application: Used as a therapeutic drug for osteoarthritis and rheumatoid arthritis, as a sweetener and food additive

Physical and chemical properties

Natural D-glucosamine exists in the form of 6-phosphate ester, which is the biochemical precursor of all amino sugars. In the first step of the aminohexose synthesis pathway, glucosamine 6-phosphate is synthesized from fructose-6-phosphate and glutamine. The final product of the synthesis pathway is uridine diphosphate N-acetylglucosamine (UDP GlcNAc), which is a N-acetylglucosamine residue donor for glycosaminoglycans, proteoglycans, lipopolysaccharides, etc.

Specific rotation 42 ° (c=2, water, 2 hours)

Application

health products

Because glucosamine is a precursor of glycosaminoglycans (mucopolysaccharides), which are the main components of articular cartilage, glucosamine is often used as an adjuvant therapy for osteoarthritis. Supplementing glucosamine may help rebuild cartilage and treat arthritis, but there is currently no consensus in the medical community on its efficacy. Experiments have shown that glucosamine is not more effective in alleviating pain than the placebo used in the reference group.

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